Member:

I remember when I was hospitalized in your hospital a few years ago, I learned that a Korean son, who had arm sarcoma, went to New Zealand to receive Coley toxin. It is said that it is also a bacterial component. Is this toxin the same as the combined immunity you use?

Xu Kecheng:

This Korean patient was hospitalized in our hospital several times. Coley toxin is a combination of two bacteria, inactivated Streptococcus and Serratia. It was more than a hundred years ago. Coley, an orthopedic surgeon at the Memorial Sloan-Kettering Hospital in the United States, found that osteosarcoma patients infected with erysipelas (streptococcal infection) had high fever, and after a period of time, the tumor retracted. So he used the so-called Coley toxin composed of inactivated bacteria to treat many sarcoma patients and solid cancer patients. In the first half of the last century, it was written in American surgical textbooks: Coley toxin should be injected after cancer surgery. But Coley's achievements were suppressed and treated unfairly. It was not until a few years ago that people brought up Coley's toxin again, believing it to be the first "tumor immunotherapy", and Coley was also hailed as the "father of tumor immunotherapy".

Member:

I heard from the father of the Korean patient that the "drug" they had in New Zealand was a complete copy of Coley's toxin, which required intravenous injection, high fever, and a very strong reaction. The combined vaccine you used was only injected subcutaneously, the reaction was only local, and the fever was also very mild. It seems that this drug is most suitable for patients like us.

(To be continued)