—— World's First Non-invasive Renal Targeted Repair System, Pioneering a New Path for Physical Therapy of Chronic Kidney Diseases

Product Positioning

　　Nephrospec is an innovative medical device adopting extracorporeal lowenergy shock wave technology. It delivers noninvasive treatment for chronic kidney disease (CKD) and associated hypertension by precisely activating the kidney’s selfhealing mechanism.This product obtained CE certification and patents in 2016, and has been launched in multiple regions including Israel and the Philippines.

Technical Advantages

• Precise Targeting: Shock waves are accurately delivered to renal microvascular regions via a special focusing device.

• Dual Mechanisms: Mechanical stress and cavitation effect synergistically activate cellular mechanoreceptor proteins.

• Autologous Repair: Stimulates angiogenic signaling factors to promote renal microvascular reconstruction.

• Fully Noninvasive: Extracorporeal therapy avoids risk sassociated with interventional surgey.

Indications

　　Intended to improve renal blood flow for the treatment of hypertension in patients diagnosed with chronic kidney disease (CKD).

Clinical Value

• Blood Pressure Control: Average systolic blood pressure reduction of 10–15mmHg with efficacy sustained for 12 months.

• Functional Improvement: Elevated eGFR and significantly reduced urinary protein.

• Dialysis Delay: Effectively slows disease progression, cutting more than 80% of dialysisrelated costs.